Cultural activities (e.g., visiting museums, dancing, arts and crafts, creative activities etc.) are believed to improve our mental health, but artists who are intensively engaged in those activities are found to be prone to mental health problem. This contradiction raises the question: Does cultural engagement really benefit mental health, and if so, under which conditions? Self-selection (niche picking), individual differences in interests and talents, and familial factors (both genetic and family upbringing) certainly play an important role. Apart from familial confounding, differences in the type of cultural engagement will likely play a role, such as - professional versus amateur/recreational, active versus passive (e.g., music listening vs. playing), and social versus solitary (singing in a choir vs. alone). To test those possibilities, this project uses a dataset composed of thousands of genotyped twins and applies methods like multivariate regression, co-twin control design, polygenic score, and structural equation modeling to disentangle (1) genetic and environmental contributions to those relationships and (2) underlying correlations, causations, mediations, and moderations.